I could not find a story at Fox, CNN or MSN sites yet, just the Breaking News banner. I'll update with links when available.
Update: Breitbart has the following from the AP:
BUFFALO, N.Y. (AP) - New York state police say a 50-passenger commuter plane has crashed into a home in suburban Buffalo. There was no immediate information on injuries.
State Trooper John Manthey says the plane hit a house in Clarence around 10:10 p.m. Thursday.
Flames erupted from remnants of the house and aircraft as firefighters sought to control the blaze.
Manthey says they don't know whether there were any passengers on the plane. They also don't know if there were any injuries in the home.
Clarence is about 20 miles northeast of Buffalo.
Manthey says the plane may have been headed to Buffalo Niagara International Airport. He says authorities have called the Federal Aviation Administration.